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These physiological processes prevent oral doses from resulting in therapeutic plasma concentrations sufficient for significant antioxidant effects in tissues, and low solubility combined with rapid metabolism reduces the time in which the antioxidant remains in its active form, compromising its efficacy in chronic diseases that require sustained action [57, 58]

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Hum Reproduc Update

Elevated MPO levels have been proposed to play an important role as a sensitive predictive marker of myocardial infarction

GRK2 up-regulation creates a positive feedback loop for catecholamine production in chromaffin cells