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NF-B drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model

Figure 5 The model tests suggested that the JTT + G model was the most suitable for GST alignments

Results We used the GSH/GSSG-Glo Assay to monitor GSH and GSSG levels and observe the oxidative stress in adherent HEK-293 cells and suspension K-562 cells dosed with menadione (Figures 3 and 4)

The K d values were determined using nonlinear least-squares analysis and the equation: where [ L ] is concentration of the peptide, [ P ] is concentration of the protein, I is the observed change of signal intensity and I max is the difference in signal intensity of the free and bound states of the protein

Therapeutic strategies aimed at inhibiting collagen crosslinking have focused on targeting key enzymes and products such as LOX, TGase, and AGEs