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Organotropism The site-specific metastasis of breast cancer is related to subtypes and divergent gene signatures of metastatic cancer cells

doi: 10.1016/j.jbc.2023.105046

anxiolytic sedatives benzodiazepines, propanediol carbamates antipsychotics phenothiazine derivatives, thioxanthine derivatives, other tricyclic compounds, butyrophenone derivatives and isosteres, diphenylbutylamine derivatives, substituted benzamides, arylpiperazine derivatives, indole derivatives, etc

These PL-PUFAs are then oxidized by iron-dependent enzymes as lipoxygenases (LOXs) or the labile iron pool into lipid hydroperoxides (PL-PUFA-OOH) to undergo the Fenton reaction under the presence of ferrous iron to trigger ferroptosis onset (Lee and Gan, 2022