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ACLY, a key cytosolic enzyme that converts mitochondrial citrate to acetyl-CoA, exerts dual effects when inhibited, it not only activates the cGAS-STING innate immune pathway but also concomitantly upregulates PD-L1 expression in cancer cells

Activated microglia are an important type of innate immune cell in the brain that secrete inflammatory cytokines into the extracellular environment, where they exert neurotoxicity on surrounding neurons by releasing nitric oxide [35,36], and are involved in the pathogenesis of many brain disorders, including AD [37]

10.1128/JVI.67.6.3246-3253.1993 [DOI] [PMC free article] [PubMed] [Google Scholar] Johansson L, Chen C, Thorell J-O, Fredriksson A, Stone-Elander S, Gafvelin G, Arnr ESJ

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