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In rodent and cell work, NNMT knockdown or inhibition has been described as protecting against diet-induced weight gain and improving metabolic measures without reducing food intake [5] [6]

Researchers wanted to isolate just the fat-burning signal and AOD-9604 was the result

Metabolic signaling pathways

The recommended daily intake of Vitamin B12 varies by age and health status: Birth to 6 months Infants 712 months Children 13 years Children 48 years Children 913 years Teens 1418 years Adults Pregnant teens and women Breastfeeding teens and women Vitamin D3 and B12 can be taken together safely, as they do not interact negatively and support overall health

You can find more scientific research on B12's role from sources like the National Institutes of Health