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Nature 583(7817):638643 Balmus G et al (2018) Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

These findings imply that TSS supplementation, in combination with aerobic exercise, holds promise in addressing oxidative stress, insulin resistance, dyslipidemia, and steatosis, key pathological features of NAFLD, by regulating AMPK/SIRT1/PGC-1 signaling and downstream metabolic and antioxidant pathways