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Sebaratnam D, 2025, 'Cost-utility analysis of sirolimus in the treatment of vascular malformations', in AUSTRALASIAN JOURNAL OF DERMATOLOGY , WILEY, Vol

Dermatology, 2013, 228: 34-36

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The lactam bridge between Asp5 and Lys10 side chains cyclises the heptapeptide backbone and constraining it into a compact, conformationally rigid structure that stabilises the receptor-binding pharmacophore conformation required for high-affinity MC3R and MC4R engagement