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All ESBLs do not respond to the same antimicrobial agents

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This novel combination approach could serve as an alternative strategy for patients with limited treatment options due to poor performance status and those who are not viable candidates for traditional therapies

In fact, hypoxia and EMT bring about increased invasiveness and metastasis of tumors mainly caused by up-regulation of c-Met, Twist, and HIF-1a [83, 84]