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The most prominent Fe-S cluster disorder is Friedreichs ataxia 163 , which affects 1:50,000 individuals

In T2D, significant apoptotic changes are seen where Bax expression is comparatively higher than Bcl-2 indicating increased apoptotic neutrophils [43]

FIGURE 5 5.2 Chronic stress and adult hippocampal neurogenesis The hippocampus serves as a critical hub for stress regulation and cognitive processing and is therefore highly relevant to cognitive dysfunction in disorders such as ME/CFS