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However, in a separate real-world study of 63 virologically suppressed people with HIV in Italy who switched to DOR/3TC/TDF from any prior ART regimen (mostly regimens containing an NNRTI [47%] or PI [32%] as the only anchor agent), a non-statistically significant median weight increase of 0.55 kg was observed over 12 months of follow-up [26]

However, not having enough B12 can lower the sperm count and also cause problems with ovulation and implantation

This is why FDA-approved options exist for chronic weight management (for people who meet criteria)

Drawing past your target then pushing back down also helps clear stubborn ones