glutathione s transferase review article Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation Schematic representation of the structure

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In addition to small-molecular antioxidants, extracellular antioxidant defense against ROS is also mediated by SOD mimetic compounds, capable of scavenging superoxide radicals and preventing the formation of damaging peroxynitrite, formed by the reaction between superoxide and nitric oxide

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Elevated DKK1 levels in the bloodstream and bone microenvironment have been linked to enhanced cancer development through the modulation of -catenin levels in MDSCs, which can inhibit their immunosuppressive functions and support tumor growth [163]