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PMID: 9828205, DOI: 10.1002/hep.510280601

1.1 per 1,000 person-years

Current evidence suggests that both strategies are generally safe and feasible, with potential benefits ranging from improved body composition and metabolic profiles to enhanced synergy with systemic therapies and immunotherapy

Clin Endocrinol (Oxf) (2013) 79:58490

[Interesting fact treatment of OTC deficiency made headlines in 1999 when Jamie Gelsinger, an 18-year-old with mild OTC deficiency died during a gene therapy trial