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Cells were frozen in liquid nitrogen and were thawed in 37C water bath

The sustained inflammatory cascade ultimately contributes to hepatocyte death, liver dysfunction, and progression to acute liver failure in severe cases of APAP overdose (Fig

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Kim SY, Kim D, Kim J, Ko HY, Kim WJ, Park Y, Lee HW, Han DH, Kim KS, Park S, Lee M, Yun M (2022) Extracellular citrate treatment induces HIF1 degradation and inhibits the growth of low-glycolytic hepatocellular carcinoma under hypoxia

Mutations in ALDH7A1, MOCS2 , and ALDH4A1 entail build-up of reactive aldehydes (-aminoadipic semialdehyde, -glutamic semialdehyde) that may react non-enzymatically with macromolecules of brain cells