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10.1038/s41586-022-05660-7 146 PetrusP.LecoutreS.DolletL.WielC.SulenA.GaoH.et al (2020)

In bladder cancer cells, the combination of triptolide and hydroxycamptothecin significantly enhances G0/G1 phase arrest by inhibiting CDK4, CDK6, and Cyclin D1

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The importance of the endoplasmic reticulum in tumor cells has been associated with an abnormal redox state, which is likely attributable to the protein folding processes occurring within this organelle