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Additionally, the CFAX12 system can be adapted to investigate other respiratory diseases and toxic exposures, such as the effects of e-cigarette vapor or heated tobacco products on human lung health

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Locally produced IGF-1 also contributes to autocrine and paracrine signallingtissues produce their own IGF-1 in response to GH stimulation, creating local high concentrations even when systemic IGF-1 remains modest

and pH ~ 4.7 in lysosomes), 101,102 which makes the ionizable components of the nanoparticles become protonated

The raw RNA sequencing data was mapped to human reference genome hg38 using the STAR aligner 63 , and genes annotated in Gencode v36 64 was quantified using featurecounts in the subread package 65