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If you're using the same dosing schedule for both, one accumulates peptide while the other doesn't, and your dose-response curve becomes meaningless

The Phase II denomination comes from Williams classic nomenclature and can be misleading, as it reflects the notion of sequential metabolism, where the parent drug is converted to a primary (or first-generation) metabolite, which in turn is subjected

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Many studies have been conducted using MPTP-induced PD models in different species of experimental animals

TABLE 7 Summary of parameters in the PBPK model