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The intensity of the pink coloration can vary depending on the concentration of B12 in the formulation, ranging from pale pink in lower concentrations to deeper pink or light red in higher concentrations

1 H NMR (400 MHz, DMSO-d 6 ) 8.56 (m, 1H), 8.33-8.10 (m, 2H), 7.59 (m, 1H), 6.47 (m, 1H), 3.93 (m, 3H)

In todays sanitized, modern world, the water supply is commonly chlorinated to kill off any bacteria

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Moreover, smooth-fitting curve analysis identified a threshold effect: below 358.7 pg/mL, each 10 pg/mL increase in vitamin B12 was associated with a 4.4% increase in clinical pregnancy rate (OR = 1.04, P = 0.03), beyond which no further benefit was observed