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3 , e01607 (2013)

As a macromolecular molecule, APS are insoluble in water, have a low oral absorption rate and a low bioavailability, and are quickly affected by stomach acid and other variables, resulting in a highly limited therapeutic effectiveness

Future research should explore the bidirectional crosstalk between sex hormones and mitochondrial signaling, paving the way for more precise and safer therapeutic strategies tailored to individual pathophysiological profiles