DOI:10.1111/1523-1747.ep12465218 [ Links ] 72
10.1111/bph.13847 26 IsraelY.KarahanianE.EzquerF.MoralesP.EzquerM.Rivera-MezaM.et al
Oligo sequences for competition library: Human SLC25A40 sg1 F: caccGGTTGGATTTCCCTTTGGAG, sg1 R: aaacCTCCAAAGGGAAATCCAACC, sg5 F: caccgAAGAGGGAGGCAACAAACTA, sg5 R: aaacTAGTTTGTTGCCTCCCTCTTc, sg6 F: caccgAAGAAGCCAGGAAATTTCCA, sg6 R: aaacTGGAAATTTCCTGGCTTCTTc, sg7 F: caccGGTACATCTCTAAGAACAGT, sg7 R: aaacACTGTTCTTAGAGATGTACC, sg8 F: caccgCTATGTGTCTGTGAAGAGGG, sg8 R: aaacCCCTCTTCACAGACACATAGc, Human TXNRD2 sg2 F: caccgTAAACCACTGGAGTTCACGG, sg2 R: aaacCCGTGAACTCCAGTGGTTTAc, sg3 F: caccGATTAGGAGGGCGCTTCCGG, sg3 R: aaacCCGGAAGCGCCCTCCTAATC, sg6 F: caccgCAAGAAGCTGATGCACCAGG, sg6 R: aaacCCTGGTGCATCAGCTTCTTGc, sg7 F: caccGCACTACCTGGTCGAAGCCG, sg7 R: aaacCGGCTTCGACCAGGTAGTGC, sg8 F: caccGGAGGACAGCACCACCGGCA, sg8 R: aaacTGCCGGTGGTGCTGTCCTCC, Control sg5 F: GCGGATTAGAGGTAATGCGG, sg5 R: CCGCATTACCTCTAATCCGC, sg6 F: GGAGCCATGGTAGAGCGTAT, sg6 R: ATACGCTCTACCATGGCTCC, sg11 F: GGCGCTCGATTAAGACTCAG, sg11 R: CTGAGTCTTAATCGAGCGCC, sg12 F: GTTACGCGTGCTGTCGCTTC, sg12 R: GAAGCGACAGCACGCGTAAC, sg13 F: GTTCCTTCTGCAGGCACGCT, sg13 R: AGCGTGCCTGCAGAAGGAAC Analysis of transcriptome-wide association studies (TWAS) data We analyzed transcriptome-wide association studies (TWAS) results on 4,000 traits for SLC25A39 in the UK Biobank 12 (n=361,194) using the summary-statistics-based, joint-tissue PrediXcan 51,52
Keywords: A and oxidative damage, Alzheimer disease and lipid peroxidation and protein oxidation, Alzheimer disease and translational approaches, Down syndrome and Alzheimer disease and oxidative stress, oxidative stress and energy dysmetabolism Abstract Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms, among which oxidative stress (OS) appears as a major determinant
