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Once activated by AMPH, a subset of intracellular TAAR1 receptors couples to the activation of the small GTPase RhoA, activating a pathway that leads to the internalization of the DAT, as well as of EAAT3 [4]

A study utilizing TCR sequencing and CITE-seq/transcriptome analysis in MM showed that greater baseline TCR diversity was associated with longer PFS, while increased clonal expansion of terminally differentiated T cell clones correlated with shorter PFS [140]

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Mediating ferroptosis may help provide specific molecular targets for suppressing oncogenesis, and can be used in estimating prognosis of neoplastic diseases