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Additional oral calcium supplementation at a dose of 1.2 g/day when co-administered with metformin has previously shown to partially mitigate this effect of metformin suggesting its potential role in prevention of B12 deficiency

Zinc in cellular regulation: the nature and significance of zinc signals. Int J Mol Sci

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By bioinformatic analysis of microarray data in the GEO database, it has been identified that ZnT10 is one of the ten recommended candidate genes associated with CRC