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Description

N Engl J Med 368:13581360

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Prescribing information (Novo Nordisk, 2025)

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Systemic bacterial infections

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TRPV1 Channel Inhibition: Research published in Molecular Immunology (2023) identified a second direct analgesic mechanism ARA-290 specifically inhibits TRPV1 (Transient Receptor Potential Vanilloid 1) channel activity in peripheral nociceptors, increasing the pain threshold and relieving mechanical hypersensitivity independent of its anti-inflammatory IRR actions

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March 2024

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