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Multiple sclerosis (MS) Multiple sclerosis (MS) is a neurodegenerative disease that disrupts the BBB and eventually allows CD4 + T cells, peripheral macrophages, and B cells to enter into CNS

The role and interplay between these enzymes that prevent H 2 O 2 accumulation in the erythrocyte has been a topic of discussion over the years

Long-term corticosteroid use can have similar effects, additionally depleting B12

Researchers have found that extracellular acidification is linked with more aggressive tumor behaviors through upregulating ProMMP9/MMP9 expression, disrupting intercellular adhesion, and clearing obstacles for metastasis [217, 218]

Nrf2 is a transcription factor of the basic region leucine zipper family[125]