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The upregulation of key glycolytic enzymes, such as hexokinase 2 (HK2), pyruvate kinase M2 (PKM2), and lactate dehydrogenase A (LDHA), remains a hallmark of many NSCLC tumors [12, 13]

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Both doses were safe and well tolerated, but the high-dose regimen achieved markedly higher plasma concentrations and produced a faster, greater reduction in SOFA scores and inflammatory biomarkers (CRP and procalcitonin), while preventing thrombomodulin elevation (Fowler et al., 2014)

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