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In a similar study, the pivotal role for the IGF-1 in insulin sensitivity has received further support from liver-specific IGF-1 KO mice which exhibited overt insulin resistance and hyperinsulinaemia that was reversed by the administration of IGF-1 [161]

Mol Metabolism

Roura, E

Thus, both processes, i.e., protein adducts formation and the oxidant stress, are essential features of APAP-induced cell death and depend on each other