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Am J Gastroenterol (2003) 98:203441.10.1111/j.1572-0241.2003.07660.x 100 SummersRWElliottDEUrbanJFJrThompsonRAWeinstockJV

FDA also identified potential immunogenicity concerns associated with peptide aggregation and related impurities

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Compared to its sister vaccine VBI-2902, which only contains the ancestral Wuhan-Hu-1 spike, VBI-2901 generated a 2.5-fold stronger response to the ancestral strain and a ninefold stronger response against the bat coronavirus [148]