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Abstract GPCR desensitization is a general regulatory mechanism adopted by biological organisms against overstimulation of G protein-coupled receptors

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KA is a glutamate receptor antagonist that blocks the NMDA receptor of glutamate and acts as a scavenger of free radicals, such as the hydroxyl radical or superoxide ( In the pathophysiology of depressive disorders, the involvement of the kynurenine pathway is more likely when reactive oxygen species are generated from 3-HK and QUIN acid

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As a result, it can lead to fatty liver disease in those who misuse alcohol and those who dont