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Annals of the New York Academy of Sciences , 2007

Associated with discontinuation in Major Depressive Disorder, OCD, bulimia, and Panic Disorder placebo-controlled clinical trials (excluding data from extensions of trials) Table 5 lists the adverse reactions associated with discontinuation of PROZAC treatment (incidence at least twice that for placebo and at least 1% for PROZAC in clinical trials collecting only a primary reaction associated with discontinuation) in Major Depressive Disorder, OCD, bulimia, and Panic Disorder clinical trials, plus non-US Panic Disorder clinical trials

Another detailed aspect of combination therapy involves the use of TGF- inhibitors alongside agents targeting other key signaling pathways implicated in fibrosis, such as the Wnt/-catenin or PI3K/Akt pathways (128)