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4.2 Oxidative Stress, PPP, and Renin-Angiotensin System 4.2.1 Oxidative Stress and PPP Under steady-state conditions, ROS are maintained in a stable range and participate in the regulation of cell growth, differentiation, apoptosis signals, and enzyme activity by modulating the production of ceramide, kinase regulatory proteins, and activation of transcription factor NFKB (238, 239)

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