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4430-A PI3K/AKT SIGNALING ON IMMUNE ESCAPE AND IMMUNE INFILTRATION IN HCC RECURRENCE Chong Wa To 1 , Soumita Ghosh 1 , Xun Zhao 1 , Elisa Pasini 2 , Sandra Elisabeth Fischer 3 , Elmar Jckel 2 , Anand Ghanekar 4 , Gonzalo Sapisochin 1 and Mamatha Bhat 1 , (1)University Health Network, (2)Ajmera Transplant Center, University of Toronto, Toronto, ON, Canada, (3)University of Toronto, (4)The Hospital for Sick Children Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease with complex mechanistic pathogenesis, which contributes to aggressive HCC recurrence

1 Introduction Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovitis and destructive arthropathy, affecting approximately 1% of the population worldwide ( Figure 1 )

doi: 10.1016/j.cell.2018.01.007 177 LazarouMSliterDAKaneLASarrafSAWangCBurmanJLet al

Histomorphometric analysis at 4 weeks demonstrated that both the local MSC and systemic MSC groups exhibited significantly higher axon counts compared to controls (local MSCs = 10,289 and systemic MSCs = 6,861 vs

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