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What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have

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doi: 10.1007/s12264-012-1273-z 141 XieT.BelinskyM.XuY.JaiswalA

Huang, K.-P

Anterodorsal thalamic cells with 5-HT2A knockouts were cultured and treated with a 5-HT2A receptor agonist