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It highlights the peptides ability to target stubborn fat through enhanced fat metabolism, including stimulating lipolysis and inhibiting fat synthesis, while preserving lean muscle mass

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Importantly, the disease causing I148M variant was a gain of function for the interaction with ABHD5 and inhibition of lipolysis, and could promote TAG accumulation in an ABHD5-dependent manner (70)

In-clinic administration provides in-person oversight but requires scheduling, travel, and per-visit costs