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doi: 10.1016/j.abb.2024.110009, 116

En 1967, Luzzatto 12 postul por lo menos dos sitios de unin del NADP a la enzima, con un estado de transicin de baja a alta afinidad cuando aumenta la concentracin de NADP, lo que significa que existen dos posibles formas de la enzima, de acuerdo con su afinidad por el NADP