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By maintaining receptor sensitivity, it avoids the receptor down-regulation often associated with long-acting GH analogues or DAC-modified peptides

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Stanley CA, Lieu YK, Hsu BY, et al

Chemotherapy Agents Although preliminary evidence suggested alpha-lipoic acid might counteract neuropathy from some chemotherapy drugs, there is a theoretical risk that antioxidants such as alpha-lipoic acid may decrease the effectiveness of chemotherapy

The degradation results in the formation of methyl-galacturonate which is converted into L-galactonate via two reactions catalyzed by methyl esterase and D-galacturonate reductase