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In the HG-3 cell line, the CB-839 and venetoclax combination did not demonstrate strong synergism

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In some embodiments, acylating the amino acid conjugate or peptide conjugate so as to replace the amino protecting group at R9 with L3-C(O) comprises removing the amino protecting group at R9 to provide a hydrogen at R9

Cytosolic Grx-roGFP2 is not detectably disturbed upon Ca 2+ release In the ER lumen, the GSH/GSSG redox couple is shifted towards its oxidized form as a result of oxidative protein folding and the restricted permeability of GSSG through the ER membrane [16]

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