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Consistent with the OEM, experiments have demonstrated that in confinement, aquaporin 5 and the sodium-hydrogen exchanger 1 (NHE1) localize at the cell front, promoting isosmotic cell swelling [162]

[1] [2] Neurological protection: Prompt B12 replacement prevents irreversible neurological damage in deficiency states, including subacute combined degeneration of the spinal cord

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Excessive B12 intake is generally considered safe, as the body typically excretes any surplus through urine