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AML is characterized by the accumulation and blocked differentiation of progenitors of myeloid, monocytic, erythroid, or megakaryocytic lineage, and ALL instead arises from the transformation of B-cell (B-ALL) or T-cell progenitors (T-ALL) ( Although the use of various chemotherapy schemes for the treatment of ALs has achieved a high percentage of survival in developed countries, in Colombia its implementation has shown discouraging results, with complete remission rates of 45% in AML and 61% in ALL in the adult population (Sossa et al., 2021)

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Growth hormone secretion follows a circadian rhythm with the largest pulse occurring 6090 minutes after sleep onset

The process by which SHMT inhibition occurs as a result of PTX exposure was successfully identified in vitro, a finding that emerged through the employment of human recombinant proteins [159]