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The antioxidant defense network, composed of antioxidants such as polyphenols, ascorbic acid, vitamin A, -lipoic acid, thioredoxin (Trx), glutathione (GSH), melatonin, coenzyme Q, -carotene, and -tocopherol, along with antioxidant enzymes including catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), and glutathione reductase (GR) ( 3 Core pathological mechanisms of ROS-mediated skin diseases Reactive oxygen species play complex and critical roles in the occurrence and development of skin diseases (Figure 2), with pathological mechanisms involving multiple levels, including abnormal cell signaling pathways, regulation of inflammatory responses, and direct oxidative damage

Fast and efficient phase II metabolism keeps toxic metabolites moving out of the body quickly

Asian Pac J Cancer Prev (2013) 14(9):5199205

doi: 10.3390/ani10071192 44 StanawayJ

Results of a previous study revealed that baicalein promotes ferroptosis through inhibition of the JAK2/STAT3/GPX4 signaling pathway