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A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome

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In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]

These findings illuminate the physiologic significance as well as pathogenic implications of microproteins, an emerging class of proteins from the dark proteome (Jiang et al, 2021