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doi: 10.1016/j.ccell.2022.05.013 97 KleinJWoodJJaycoxJRDhodapkarRMLuPGehlhausenJRet al

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46,47,48 In 2005, the discovery of pseudouridine () modification addressed the immunogenicity issue of in vitro-synthesized mRNA, 49 leading to the initiation of the first human trial of an mRNA vaccine against melanoma in 2008