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5-Amino-1MQ binds at the NNMT substrate site (IC = 1.2 M), selectively, without affecting related methyltransferases

Cognitive Support Higher NAD levels activate sirtuins 10 (SIRT1, SIRT3), which protect brain cells by reducing oxidative stress, supporting DNA repair, and improving mitochondrial health

Inhibiting this pathway leads to enhanced fat metabolism and improved glucose tolerance. Hong et al., Nature Medicine Biohackers and Longevity Enthusiasts Because it increases NAD a key coenzyme in energy metabolism, DNA repair, and aging 5-Amino-1MQ may appeal to those looking to extend healthspan, improve cellular resilience, and combat age-related decline