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Description

Gragasin FS, Michelakis ED, Hogan A, Moudgil R, Hashimoto K, Wu X, et al

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doi: 10.1172/jci.insight.120360 225 RodigSJGusenleitnerDJacksonDGGjiniEGiobbie-HurderAJinCet al

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This interaction with ACE2 seems to be primed by a proteolytic cleavage of the spike (S) protein by the transmembrane protease serine (TMPRSS2), responsible for the virus interaction with its target receptor (Hoffmann et al., 2020

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R.MisraS

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This work also made use of the Genomics Core Facility supported by NIH P20-GM103528 (TWG) and NIH 2P30 DK072476

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