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In sick dogs, oxidative stress can increase, and glutathione is one of the key internal compounds involved in reducing that load

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Interestingly, some previous studies have shown that DHFR levels or activity are diminished in experimental models of cardiovascular disease states, suggesting that insufficient recycling of BH2BH4 by DHFR is at least in part responsible for the reduced BH4 levels and the accumulation of BH2, leading to eNOS uncoupling

As always, any intervention should be discussed with your healthcare provider