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NAC is the primary option for patients with liver injury requiring pharmacological treatment ( FIGURE 5 Because of the absolute role of mitochondrial oxidative stress and dysfunction in the pathogenesis of AILI, the FDA approved the antioxidant NAC in 2004 to treat intrinsic DILI caused by excessive APAP intake

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The detailed analysis of the differences in the sample size, in the number of RCTs included for each outcome, and in the results between the present study and the Cochrane meta-analysis is detailed in Table 3

doi: 10.1016/s0006-2952(00)00556-6

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