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They performed experiments on human hepatic L02 cells treated with CdCl2 and found that Drp1 and retinoblastoma (RB) protein levels were increased and translocated to mitochondria in CdCl 2 -treated cells

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Hazen, Chair of the Department of Cardiovascular and Metabolic Sciences at Cleveland Clinic and senior author of the recent study

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Many spin traps react relatively ineffectively with superoxide (e.g., PBN has weak in vitro antioxidant activity), so high doses are required to achieve a therapeutic benefit