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Serving as an essential cofactor for numerous enzymatic reactions, it plays a pivotal role in maintaining cellular functions and physiological homeostasis

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Tumor cells with dysregulated nitrogen metabolism or impaired urea-cycle activity can release elevated levels of ammonia, which may impose a chronic metabolic burden on infiltrating lymphocytes (Zhang H

Results Immuno-metabolic profiling of monocyte to DC differentiation reveals extensive reprogramming from glycolytic to predominantly mitochondrial metabolism To evaluate the impact of metabolic pathway inhibition during monocytic DC differentiation, we employed SCENITH coupled with a multi-parametric panel encompassing DC surface and signaling markers (Fig