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Advances in nanomedicine and targeted delivery systems will also be essential to improve therapeutic specificity and reduce toxicity

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Bock P, Friedel W, Hanisch J, Karasmann M, Schneider B

Nanoparticles with PEG densities below 0.2 molecules per nm are insufficient to prevent opsonisation and rapid MPS-mediated clearance [249], while coatings exceeding ~ 20 PEG chains (5 kDa each) per 100 nm consistently prolong circulation, independent of nanoparticle size