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The successful application of drugs targeting p53 will certainly be a breakthrough owing to the widespread occurrence of p53 mutations

Concurrently, the E3 ligase ZNRF2 tunes the ubiquitination of the auxiliary subunit SLC3A2 at K147, driving its plasma membrane translocation to maximize cystine import in lung adenocarcinoma, which can be therapeutically blocked by the synthetic peptide K147 [36]