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The underlying mechanisms involve multi-pathway synergistic regulation: down-regulating pro-inflammatory factors such as IL-1 and IL-6 while up-regulating IL-10 (113), thereby blocking the neuroinflammatory cascade (114)

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Studies have found that in HS models, heat stress can mediate the phosphorylation of ERK1/2 through receptor-interacting protein 1 (RIP1

For the record, the body selenium content is about 10 to 20 mg, and the plasma compartment contains only a small fraction of body selenium content (less than 2%)