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it's about understanding the pharmacokinetics to design protocols that are repeatable, reliable, and produce clear data

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Gnecco JS, Brown A, Buttrey K, Ives C, Goods BA, Baugh L, Hernandez-Gordillo V, Loring M, Isaacson KB, Griffith LG (2023) Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk

The use of cyclosporine A as monotherapy was reported in 137 patients and provided an ORR of 83.2% (95% CI, 72.3-94.1, I 2 , 58%), whereas 124 patients were reported to receive cyclosporine combined with corticosteroids, providing an ORR of 77.3% (95% CI, 69.9-84.7, I 2 , 0%)